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KMID : 0613820080180030311
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Journal of Life Science
2008 Volume.18 No. 3 p.311 ~ p.317
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Suppression of Reactive Oxygen Species Production by Water-extracts of Coptidis Rhizoma Enhances Neuronal Survival in a Hypoxic Model of Cultured Rat Cortical Cells
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Choi Ju-Li
Shin Gil-Cho
Lee Won-Chul
Moon Il-Soo
Jeong Seung-Hyun
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Abstract
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Pathophysiological oxidative stress results in neuronal cell death mainly due to the generation reactive oxygen species (ROS). In low oxygen situation such as hypoxia and ischemia, excessive ROS is generated. Coptidis Rhizoma (CR) is a traditional medicine used for the incipient stroke. In this report we show that CR water extracts exhibited protective effects of neuronal cell death in a hypoxic model (2% 3 hr) of cultured rat cortical cells. We further show that CR water extracts significantly reduced the intensity of green fluorescence after staining with on one hour and three days after hypoxic shock and in normoxia as well. Our results indicate that CR water extracts prevent neuronal death by suppressing ROS generation.
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KEYWORD
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Coptidis Rhizoma, cortical culture, hypoxia, neuron, reactive oxygen species
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